New PDF release: Advances in Applied Microbiology, Vol. 44

By Saul L. Neidleman

ISBN-10: 0120026449

ISBN-13: 9780120026449

Compliment for the sequence "No laboratory scientist, box employee or technical administrator can have enough money to go it up." --ASM information "The themes are good supported by means of an in depth bibliography and supply a wealthy resource of present information." --Biopharm

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STRUCTURES 92-97. $D F 32 CEDRIC PEAFCE ing malt extract, glucose, yeast extract, and ammonium sulfate. The screening bioassay consisted of malt agar plates containing vegetative mycelia of r! destructiva. Samples were spotted on the surface of these plates, and cytodifferentiation was measured by the zone of pigmentation produced around the site of sample application. 5 pg/ml against Sporobolomyces salmonicolor and Phoma destructiva. , 1995). In this case, the metabolites contained 18 amino acid residues compared to 19 in the chrysospermins, so that belong to the recognized group of long-sequence peptaibols.

A number of compounds containing bicyclic decalin and related structures with a variety of bioactivity, but commonly antifungal, have been reported recently. Thus, the diepoxins 100-103 (Schlingmann et BIOLOGICALLY ACTIVE FUNGAL METABOLITES 35 (107) Australifungin OH (108) Australifunginol STRUCTURES 107, 108. , 1993) were obtained from fermentations of a Mycelia sterilia initially isolated from a Panamanian tree sample at MYCOsearch. Of the four diepoxins reported, 101was inactive, but the remaining three had some antibacterial activity and inhibited C.

1995) investigated a mutant of the patulin-producing Penicillium urticae, which was shown to produce a new azaphilone epoxide, patulodin (117a). This compound was shown to be weakly antifungal, having an MIC value of 50 p g h l against Pyricularia oryzae. As with the discovery of antiinsectan compounds (discussed in Section XI), Gloer and co-workers (1995a, 1996) have used an elegant discovery approach directed by nature and have sought antifungal compounds from fungi living in environments wherein the fungal inhabitants might be reasonably expected to compete for nutrients with each other.

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Advances in Applied Microbiology, Vol. 44 by Saul L. Neidleman

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