By Marlene A. Jacobson (auth.), Luiz Belardinelli, Amir Pelleg (eds.)
This ebook includes a choice of lectures given in the course of the fifth foreign Symposium on Adenosine and Adenine Nucleotides, lately held in Philadelphia, Pennsylvania.
Adenosine and Adenine Nucleotides: From Molecular Biology toIntegrative Physiology covers a variety of matters from molecular and mobile biology to scientific purposes. a superb emphasis has been put on innovative details derived from experiences utilizing molecular and mobile biology recommendations utilized to the sector of adenosine and adenine nucleotide examine. The ebook additionally contains info on very likely promising advancements within the healing functions of adenosine comparable medicines and ATP. The culture of earlier conferences can be maintained by means of together with within the software shows of latest learn within the parts of purine metabolism and body structure, and pharmacology of adenosine and adenine nucleotides.
Adenosine and Adenine Nucleotides: From Molecular Biology toIntegrative Physiology is a wonderful, up to date reference booklet for easy and scientific scientists within the box of adenosine and adenine nucleotides.
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Additional info for Adenosine and Adenine Nucleotides: From Molecular Biology to Integrative Physiology
Mol EndocrinoI5:1037-1048. Mahan LC, McVittie LD, Smyk-Randall EM, Nakata H, Monsma F] ]r, Gerfen CR, Sibley DR (1991) Cloning and expression of an Al adenosine receptor from rat brain. Mol Pharmacol 40: 1-7 . Fink ]S, Weaver DR, Rivkees SA, Peterfreund RA, Pollack AE, Adler EM, Reppert SM (1992) Molecular cloning of the rat A2 adenosine receptor: Selective co-expression with D2 dopamine receptors in rat striatum. Mol Brain Res 14:186-195. Schiffmann SN, Vanderhaeghen J] (1992) Ontogeny of gene expression of adenosine A2 receptor in the striatum: Early localization in the patch compartment.
This particular orientation appears to have more general validity, since longer C8 substituents, CPA SHA 174 A FIGURE 4-5. A: Receptor-bound conformations of CPA (AI receptor) and SHA 174 (Az receptor). Atoms as in Figure 4-3A. B: Receptor-bound conformations of N 6 -cyclopentyladenosine (CPA) and 1,3-dipropyl-8cyclopentylxanthine (DPCPX). Atoms as in Figure 4-3A. 4. MOLECULAR MODELING OF Al AND A2a RECEPTORS 33 DPCPX B FIGURE 4-5. Continued as in the xanthine amine congener (XAC), can also be accommodated.
4. MOLECULAR MODELING OF ADENOSINE Al AND A2a RECEPTORS Ad P. IJ zerman Nora M. M. van Galen Ken A. Jacobson The superfamily of G-protein-coupled receptors encompasses over 300 cloned and sequenced members, and this number is still rapidly growing. Among them are the adenosine receptor subtypes-AI' A2a , A2b , and A 3-some of which originate from various species. Adenosine receptors also show the characteristic secondary structure of all G-protein-coupled receptors, that is, seven predominantly hydrophobic stretches of 20-25 amino acids that could span the cell membrane as a-helices (Fig.
Adenosine and Adenine Nucleotides: From Molecular Biology to Integrative Physiology by Marlene A. Jacobson (auth.), Luiz Belardinelli, Amir Pelleg (eds.)